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St Patrick's Cathedral in NYC: This incredible Gothic white-marble-and-stone structure is the largest Roman Catholic cathedral in the United States, as well as the seat of the Archdiocese of New York. Designed by James Renwick, begun in 1859, and consecrated in 1879, St. Patrick's wasn't completed until 1906. The Cathedral seats about 2,200 people. After the death of the beloved John Cardinal O'Connor in 2000, Pope John Paul II installed Bishop Edward Egan, whom he elevated to cardinal in 2001. The vast cathedral seats a congregation of 2,200; if you don't want to come for Mass, you can pop in between services to get a look at the impressive interior. The St. Michael and St. Louis altar came from Tiffany & Co. (also located here on Fifth Ave.), while the St. Elizabeth altar -- honoring Mother Elizabeth Ann Seton, the first American-born saint -- was designed by Paolo Medici of Rome.